What is the cause of schizophrenia? This serious mental illness affects More than 20 million people around the world It is characterized by recurrence hallucinations and delusions, and often starts to appear from adolescence to early adulthood. It is a complex disorder that affects almost all realms of life.
Current theory of why schizophrenia occurs propose It may be associated with changes in brain development during this important period of emerging adults.
There is also schizophrenia I thought it was similar Nerve development under conditions such as dyslexia, autism and attention deficit hyperactivity disorder (ADHD), but generally appears in childhood.
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but, Our research Accelerated brain aging can be another potential driver in the development of schizophrenia, which can be measured using a simple blood test.
Our study is unique because we measured proteins in blood derived directly from brain neurons (brain neurons) of people suffering from schizophrenia. This protein, called neurological filament optical protein (NFL), consists of a long, thread -like structure that helps to maintain the size and shape of nerve cells.
NFL is released with blood and cerebrospinal fluid when brain neurons are damaged or nerve degeneration. When this cell is damaged, the release Useful biomarker Diagnose and monitor neuromoduscular diseases and neurological damage. Measuring NFL levels can provide insight into neuron damage.
Neuron damage is damage or damage of neurons, which are essential for communication in the brain, spinal cord and peripheral nervous system. When neurons are damaged, the ability to function properly can be damaged, which can cause various neurological symptoms depending on the severity and location of the damage.
The level of NFL is associated with a variety of neurological conditions, including Alzheimer’s disease, multiple sclerosis, Parkinson’s disease and frontal lobe dementia. But there is also NFL level In general, it increases with age These proteins effectively lose their ability to recover themselves. This is due to the combination of factors, including the gradual wear of neurons over time.
The reduction in the reduction of the gray protein, the protein and connectivity of the brain is part of normal and healthy aging, but these changes are generally gradual and not disabled.
The gray protein contains most brain neurons and is responsible for information, memory, decision -making, muscle control, reporting and hearing processing. Protein can communicate quickly and efficiently with a long fiber that connects other brain regions.
Normal and healthy brain aging symptoms can include a little bit more forgiveness, reaction time, and difficulty in juggling. These changes are very different from the patterns found in diseases such as schizophrenia. Our research showsThe decrease is faster and more serious, indicating an older brain age than the patient’s chronological age.
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According to our study, patients with schizophrenia have shown that NFL levels increase faster as they age, indicating the acceleration of brain aging process compared to the growth rate of healthy people.
We also studied samples of people suffering from bipolar disorders, which did not show the same acceleration. Data data Different wayIt is pointed out that the brain aging of patients with schizophrenia, such as calculating “brain age” in the MRI scan, accelerates.
Lifestyle factor
For those who suffer from schizophrenia, Melbourne’s psychiatrist and senior author of our study, Christos Pantelis, explains the following as follows.
An important problem is that patients with chronic schizophrenia are often All life forms that are harmful to health. They can experience the will of isolation, unemployment, lack of physical activity, smoking -illegal drug use. Can worsen the condition.
There are currently people who have been diagnosed with schizophrenia Lifespan 20-30 years shorter than average. This is mainly due to the initial development of general age -related diseases such as cancer. Cardiovascular disease.
Half People with schizophrenia have other chronic medical conditions such as obesity, respiratory conditions, chronic pain and drug use disorders.
People with schizophrenia have Higher risk Drug use disorders due to combination of biological, psychological and environmental factors. This includes self -treatment of pain, cognitive dysfunction, social isolation and compliance with treatment.
Lifestyle is a factor of accelerated aging of the body for those with schizophrenia, but our research can understand this painful disease and prove other important stages over time.
Alexander F SantilloAssociate professor of psychiatrist, consultant psychiatrist, Lund University; Cassandra WananPsychosis Research Institute, Melbourne Universityand Dhamidhu EratneNeuropsychiatrist and PHD student, Melbourne University
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