You always have a space for sugar treatment
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Even after a big meal, most people can still find a space for sweets. Now, a study on the mouse shows that the neurons in charge of fullness are neurons that cause sugar craving. In other words, there seems to be a neurological basis for our love for desserts.
Previous studies show that opioids that occur naturally in the brain play an important role in sugar craving. The main producer of this opioide is a neuron located in the brain region that regulates appetite, metabolism and hormones called arched nucleus in the hypothalamus. These cells, known as Pro-OPIOMELANOCORTIN (POMC) neurons, also control the feeling of satiety after meals.
To understand if cells play a role in sugar craving Henning Fenselau Max Planck Instit of the German Max Planck (Max Planck Instit they did so by taking a brain slice from three mice in a fluorescent solution that binds to the receptors of these opioids.
The highest density of these receptors was the brain core of the awards (PVT), which is known to control feed supply and other behavior. It suggested that the craving of sugar is related to the communication between these two brain regions, that is, the arched nucleus and PVT in the hypothalamus.
Therefore, the researchers monitored neurons in these areas when mice ate ordinary food. After 90 minutes, the animals seemed to be full. They were only blocked by additional food. At that point, the team poured sugar to them.
On average, the neuron activity between the brain area was about four times, and the mouse ate desserts compared to when eating regular meals. Spike started before eating sweets and suggested that the brain passage ordered sugar.
The researchers used the technology to turn on and off the cells with the light of cell genetics. When they suppressed signals from POMC neurons to PVT, the mouse consumed a 40 % less dessert.
Fenselau said, “The cell type, known for its satiety, releases a signal that causes the appetite of sugar, especially in the state. “This is an animal-an excessive consumption sugar will be explained when humans are actually full.”
We do not know why this path has evolved from animals. Fenselau said it could be because sugar was converted into energy more easily than other sources such as fat or protein. Therefore, eating desserts can be almost the same as toking a gas tank.
He hopes that this study can lead to a new treatment for obesity, but hunger and craving are complicated in everyday life. “Of course, there are many other paths in the brain, so of course you can ignore this. We found this path, but we do not know now with many others. ”
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