vaccine shingles A new study using a quirky thing in the Wales Vaccine Roll Out System can be protected from dementia.
Shingles is characterized by localized blisters, which greatly affects adults with chickenpox. that Chickenpox A virus that causes two conditions Introduce the nervous system It only appears again after the symptoms of chickenpox disappear before the dormant state falls.
There is evidence that general viral infections, such as shingles, can contribute to the development of Alzheimer’s disease by seeding amyloid plaque, which is thought to cause neuromrorism. If true, vaccines that protect people from viruses can get more advantage in reducing dementia risks, and one disease increases.
Testing these theories is difficult, but the team led by the Stanford University Medical Research Institute has now offered a solid data that is only obtained instead of randomly random trials.
“In contrast, in contrast to the evidence of correlation, we use the fact that in Wales, we have been determined based on the exact date of birth of an individual in Wales.” write.
As of September 1, 2013, Wales Eo citizens under 79 years of age were eligible to receive shingles vaccines for a year, and all over 80 years old were exempted from the limited supply of vaccines.
Then the team compared the detailed health records. 282,541 Adults of vaccinations and non -similar ages appear in just a few weeks on the cut off date.
At the end of the 2020 study period, one in eight participants was newly diagnosed with dementia. Those who were diagnosed with dementia before 2013 were excluded from the results.
Dementia has decreased by 20 % of those who have received shingles vaccines.
In the study of the association on vaccines, similar results have been found in the past, but lifestyle factors related to individuals are difficult to choose vaccinations or identify causal connections.
On the other hand, the vaccine policy with Wales Eo created a natural experiment that separates the effects of the vaccine within two groups that are statistically the same.
Not only is it more likely to receive vaccines due to eligibility, but there are few statistically different health treatment between the two large groups, for example, education levels, opioids, and other health conditions.
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The team also investigated whether the decrease in dementia risks could be the result of reducing the revitalization of vaccine viruses.
“This can occur when the virus is directly toxic to neurons, or when it promotes generalized inflammatory reactions in the nervous system of both.” Natural news and views.
“The reactivation of the virus is thought to cause the main features of amyloid -β deposit, tau aggregation and vascular damage -Alzheimer’s disease.”
The results support this theory the higher the dementia ratio among people with multiple shingles episodes.
“It is essentially the same as a random test with the control group. It is too old for the vaccine not to be qualified. Stanford Medical Professor PASCAL GELDSETZER.
His team replied the method with data from a country that follows a similar approach, including the UK, Canada, Australia and New Zealand. GELDSETZER claims that “strong protection signals for dementia” have shown in multiple data sets, but these results have not been announced yet.
This study ultimately does not confirm the shingles as a factor of dementia or that the shingles vaccine is essentially protected, but it provides a strong foundation for further investigation.
This study has been published nature.
